The baroque-inspired Betis Church was built around 1660 and it was headed by Father Jose de la Cruz. The preliminary structure was made out of light materials which was composed mainly of wood and stucco. Fire broke out within the church several times due to these light materials so it was finally built with concrete materials in 1770.

In the last quarter of 19th century, Father Manuel Camañes dug an artesian well on the north-side of the church which served as a source of potable water not only for the Betis townsfolk, but to the other nearby towns as well. On the other hand, the present-day concrete fence with caryatids was built in the 2nd quarter of the 20th century.



In 1908, the rectory of the church was burned with fire and all the documents about baptism and other historical catalogues of the church turned into ashes.

Beautification of the interior part of the church was extensively done by the last Spanish priest named Father Santiago Blanco in 1939. The ceiling paintings were repainted by a native of San Agustin named Macario Ligon. His assistant named Victor Ramos, who was in his teen years then was also the one who restored these paintings in the 1970s.

During the Spanish-Colonial period, Betis is an independent town which has its own autonomy as a municipality. But due to migration of its inhabitants to the nearby Guagua in the American Period, it was merged to this town in 1904 under the Act 943.

Today, although part of the municipality of Guagua, the Betis church has its own parochial priest and has its patron saint named St. James the Great.